Uses

What is ZENEGRA?
The active ingredient in ZENEGRA is Sildenafil Citrate. Sildenafil is used a treatment for men experiencing erectile dysfunction (difficulty maintaining an erection). Sildenafil’s mission is to work on enzymes of the body called phosphodiesterases and to improve a man’s response to sexual stimulation. These enzymes work mainly in the penis, so the action of sildenafil citrate is primarily limited to the penis.

Sildenafil works to control the enzyme, and by doing so regulates the blood flow out of the penis and thereby helping the patient maintain an erection.

Sildenafil citrate improves the erection of most men, regardless of how long they have had ED. So the time spent with one’s partner can be sexually active and arousing.

Composition:
Each film-coated tablet contains Sildenafil Citrate equivalent to Sildenafil-100mg. ZENEGRA contains the active ingredient sildenafil citrate.

Storage :
Store below 25 degree Celsius, protected from moisture.

Keep out of reach of children and it is meant for personal usage by your own doctor prescription only.

Description:
Sildenafil citrate, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Sildenafil citrate is chemically designated as 1-[[3-(6,7-dihydro-1-methyl-7- oxo-3-propyl-1H-pyrazolo[4,3-d] pyrimidin-5-yl)-4-ethoxyphenyl] sulfonyl] -4-methyl piperazine citrate and its molecular weight is 666.7.

How does Sildenafil Citrate Help?
Experts believe impotence affects between 10 and 15 million American men. In 1985, the National Ambulatory Medical Care Survey counted 525,000 doctor-office visits for erectile dysfunction. Impotence usually has a physical cause : such as disease, injury or drug side effects. Any disorder that impairs blood flow in the penis has the potential to cause impotence. Incidence rises with age: about 5 percent of men at the age of 40 and between 15 and 25 percent of men at the age of 65 experience impotence. However, it is not an inevitable part of aging.

Impotence is treatable in all age groups and awareness of this fact has been growing. More men have been seeking help and returning to near-normal sexual activity because of improved, successful treatments for impotence. Urologists, who specialize in problems of the urinary tract, have traditionally treated impotence – especially complications of impotence.

Medical History: 
Your Physician will want to know some information about your past and current health. Some of the key areas they will be concerned about are:

» Heart Problems, and Arrhythmias

» High or Low Blood Pressure

» History of Strokes

» HIV Positive Treatment

» Severe Liver or Kidney disorders

» Retinitis Pigmentosis

» Bleeding problems or Blood Conditions

Contraindications:
Nitrates
It is urgent that you inform your healthcare advisor if you are taking any form of Nitrate including amyl nitrate (poppers) or nitroglycerin. The combination of Sildenafil and nitrates may reduce the blood pressure to dangerous and perhaps even fatal levels and must never be mixed.

List of Nitrates Not to be Used with Sildenafil Citrate

Protease Inhibitors:
Protease inhibitors have been shown to substantially increase the effects of sildenafil citrate when taken together. Interaction studies of sildenafil citrate in conjunction with protease inhibitors indicated that these drugs may enhance the negative side-effects of sildenafil citrate, and because protease inhibitor drugs typically inhibit the p450 enzyme system, they may affect the metabolism of sildenafil citrate. It is recommended that a maximum single dose of 25mg sildenafil citrate in a 48 hour period for men taking sildenafil citrate in conjunction with HIV protease inhibitors (Agenerase, Norvir, Crixivan, Viracept, Invirase, Fortovase).

Other medications that may affect sildenafil citrate metabolism and your doctor will need to know about are:

» Cimetidine

» Erythomycin

» Itraconazole

» Ketaconazole

» Mibefradil

Side Effects:
The most common side effects of Sildenafil citrate are headache, flushing of the face and upset stomach. Less common side effects that may occur are temporary changes in colour vision (such as trouble telling the difference between blue and green objects or having a blue colour tinge to them), eyes being more sensitive to light or blurred vision. In rare instances, men have reported an erection that lasts many hours. You should call a doctor immediately if you ever have an erection that lasts more than 4 hours. If not treated right away, permanent damage to your penis could occur.